The Human Transporter Associated with Antigen Processing
نویسندگان
چکیده
منابع مشابه
Specific lipids modulate the transporter associated with antigen processing (TAP).
The transporter associated with antigen processing (TAP) plays a key role in adaptive immunity by translocating proteasomal degradation products from the cytosol into the endoplasmic reticulum lumen for subsequent loading onto major histocompatibility (MHC) class I molecules. For functional and structural analysis of this ATP-binding cassette complex, we established the overexpression of TAP in...
متن کاملThe peptide-binding motif for the human transporter associated with antigen processing
Presentation of antigenic peptides by human leukocyte antigen class I molecules is dependent on peptide transport into the endoplasmic reticulum by the transporters associated with antigen processing (TAP) (Germain, R. N. 1994. Cell. 76:287-299). This translocation step is currently regarded as permissive for all peptides with COOH-terminal residues capable of binding to HLA class I molecules (...
متن کاملStructure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing.
The transporter associated with antigen processing (TAP) is an ABC transporter formed of two subunits, TAP1 and TAP2, each of which has an N-terminal membrane-spanning domain and a C-terminal ABC ATPase domain. We report the structure of the C-terminal ABC ATPase domain of TAP1 (cTAP1) bound to ADP. cTAP1 forms an L-shaped molecule with two domains, a RecA-like domain and a small alpha-helical ...
متن کاملThe human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation.
In its attempt to evade cytotoxic T cell recognition, human cytomegalovirus encodes several genes that target MHC class I molecules at different points in their assembly pathway. We show here that the human cytomegalovirus US6 gene encodes a 22-kDa glycoprotein that binds the transporter-associated with antigen processing (TAP)/class I complex and inhibits translocation of peptide from the cyto...
متن کاملThe Human Transporter Associated with Antigen Processing MOLECULAR MODELS TO DESCRIBE PEPTIDE BINDING COMPETENT STATES*□
Background: The transporter associated with antigen processing (TAP) is an ABC transporter whose experimental structure is not known. Results:We have modeled TAP based on the crystal structures of three related ABC transporters. Conclusion:We identified a possible peptide binding conformation in the transport cycle of TAP. Significance:These models help interpret experimental data and give info...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2012
ISSN: 0021-9258
DOI: 10.1074/jbc.m112.381251